hrp0082p2-d1-411 | Growth Hormone | ESPE2014

Spontaneous Baseline GH Secretion Signalling as a Regulator of Bone Metabolism in Children

Decker Ralph , Andersson Bjorn , Nygren Anders , Albertsson-Wikland Kerstin

Background: GH is secreted in a pulsatile manner. The resulting GH peaks are known to be associated with growth, whereas the trough levels between the peaks are thought to be associated with metabolism in different tissues. GH trough levels were identified as a metabolically active signal in rats in the 1980th leading to differences in fat patterning with central obesity. Obese children are known to have low bone mass and bone mass is reduced in short children.<p class="ab...